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KMID : 0043320130360091078
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Archives of Pharmacal Research
2013 Volume.36 No. 9 p.1078 ~ p.1083
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Clauraila E from the roots of Clausena harmandiana and antifungal activity against Pythium insidiosum
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Sriphana Uraiwan
Thongsri Yordhathai
Prariyachatigul Chularut
Pakawatchai Chaveng
Yenjai Chavi
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Abstract
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A new carbazole alkaloid named clauraila E (1) together with 8 known compounds were isolated from the methanol extract of the roots of Clausena harmandiana. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. Pythium insidiosum is a fungus-like microorganism, for which antifungals available now are not effective. It was found that compounds 3, 6, 7 and 9 could inhibit the mycelia growth of P. insidiosum. The results show convincingly that they may be lead to compounds for the development of probiotic or novel antifungal drugs.
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KEYWORD
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Clauraila E, Clausena harmandiana, Pythiosis
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